★★★★★
"I was introduced to De Simone's VSL#3 two years ago after a bad digestion issue. A consultant suggested it. Moved to Vivomixx as couldn't get in UK. Saw it is now available under De Simone's own label. Very pleased."
Looking for VSL#3? The Original Formula is Now CDS22-formula |
🔬 VSL#3 customers — read this first
Looking for VSL#3?
Here's what happened to
the original formula.
The formula inside VSL#3 still exists. It's just called something different now.
Shop CDS22-formula — the original formula →
From £14.99 per pack · Free cold-chain delivery over £65 · Next-day UK
Cold-chain DPD — live cultures protected door to door
Next-day UK delivery available
Official UK & Ireland distributor
4.9/5 · 161 verified Trustpilot reviews
What actually happened
Three facts. No fluff.
Fact 01
VSL#3 originally contained the De Simone Formulation (DSF) — 8 specific bacterial strains, 450 billion CFU. It is the most clinically studied probiotic formulation in the world, with 80+ peer-reviewed studies.
Fact 02
In 2016 the brand changed to Vivomixx. In 2024–25 it changed again to CDS22-formula. The formulation itself — the strains, the CFU, the science — remained unchanged throughout.
Fact 03
VSL#3 today does not contain the original formula. CDS22-formula is the only product currently available in the UK still using the original De Simone Formulation.
If you were taking VSL#3 for a clinical reason and want the same formulation, CDS22-formula is what you are looking for. The brand changed. The formula did not.
Brand history notice
Previously marketed as Vivomixx® (owned by Mendes SA) until 2025 & VSL#3® (owned by Actial Srl) prior to that. No affiliation to these brands exists. CDS22-formula is an independent product distributed in the UK & Ireland by Probiotic.co.uk.
Get the original formula.
Not the copy.
Shop CDS22-formula →
From £14.99 per pack · Free cold-chain delivery over £65 · Next-day UK
450B
CFU per sachet — original DSF
8
Original De Simone strains
❄️
Cold-chain DPD delivery
🇬🇧
Official UK distributor
❄️ Free cold-chain delivery on orders over £65
3 packs: £2.65/pack shipping · 4+ packs: free shipping
3 packs: £2.65/pack shipping · 4+ packs: free shipping
Buy 2 — save £2.00
24 sachets total
£39.00
£37.00
Most popular
Buy 3 — save £8.00
36 sachets · £16.83/pack · free delivery
£58.50
£50.50
Buy 4 — save £15.50
48 sachets · free delivery
£78.00
£62.50
Buy 5 — save £23.00
60 sachets · free delivery
£97.50
£74.50
Buy 6 — save £27.01
72 sachets · £14.99/pack · free delivery
£117.00
£89.99
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VSL#3 users who found the original formula
What VSL#3 customers say after switching
4.9
/ 5 · Excellent
★★★★★
161 verified reviews
★★★★★
"Great to see Irish market offering the best range of supplements and my trusted Probiotics CDS22 aka VSL#3. I was disappointed that I couldn't buy VSL#3 from my regular UK supplier."
★★★★★
"Delivery super quick and well packaged. This is my 3rd time of ordering and it's definitely helped with my j pouch function. I'm so grateful I can still get this probiotic formula after Vivomixx stopped selling."
★★★★★
"CDS22-formula works wonders for IBD, in conjunction with other therapies. Any questions ask your consultant for advice. Although consultants are allowed to recommend it..."
★★★★★
"I used Vivomixx for quite some time then moved to CDS22-formula. This is an excellent probiotic. I have gut issues — by using CDS22 it helps me a lot. I would certainly recommend this product."
Cold-chain delivery
Live cultures. Protected all the way.
Packed cold in LancashireTemperature-controlled from the moment your order is picked at our UK facility — Matrix Park, Chorley, PR7 7NB.
Shipped refrigerated via DPDCold-chain throughout transit. Next-day delivery available nationwide. Free over £65.
Refrigerate on arrivalTransfer to your fridge immediately. Live cultures must be kept cold to maintain viability.
Full cold-chain details: probiotic.co.uk/pages/cds22-delivery-information
Shop CDS22-formula →
Clinical heritage
The most clinically studied probiotic formulation in the UK.
80+Clinical studies on this exact formulation
200+Scientific publications
450BCFU per sachet
4.9★161 Trustpilot reviews
-
Referenced in ECCO guidelines for Inflammatory Bowel Disease management (ECCO News, 2023)
-
Referenced in American College of Gastroenterology guidance for pouchitis (Olleik et al., Gastroenterology, Vol. 164, No. 6, 2023)
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NHS Patient Access Programme available via Probiotic.co.uk
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Exclusive UK & Ireland distributor — Probiotic.co.uk, Chorley, Lancashire
Common questions
VSL#3 searchers ask these
I searched for VSL#3 — am I in the right place?
Yes. The original De Simone Formulation that was inside VSL#3 is now sold as CDS22-formula. VSL#3 today has been reformulated and no longer contains the original strains. CDS22-formula is the only product in the UK still carrying the original formulation, available now with cold-chain next-day delivery.
Does VSL#3 still contain the original De Simone Formulation?
No. VSL#3 has been reformulated and no longer contains the original De Simone Formulation strains. The original formulation moved to Vivomixx in 2016 and then to CDS22-formula in 2024–25. CDS22-formula is the only product currently available in the UK that contains the original De Simone Formulation.
What is the De Simone Formulation?
The De Simone Formulation (DSF) is a specific 8-strain probiotic formulation developed by Professor Claudio De Simone. It has been the subject of over 80 peer-reviewed clinical studies and is referenced in ECCO and American College of Gastroenterology clinical guidelines. CDS22-formula contains this exact formulation.
What is the difference between VSL#3 and CDS22-formula?
VSL#3 originally contained the De Simone Formulation — 8 specific bacterial strains at 450 billion CFU. VSL#3 has since been reformulated and no longer contains those original strains. CDS22-formula contains the original De Simone Formulation — the same 8 strains, 450 billion CFU, 12 sachets per pack.
How is CDS22-formula delivered in the UK?
CDS22-formula contains live bacteria and must be refrigerated. We ship cold-chain via DPD from our temperature-controlled facility in Lancashire. Next-day delivery available nationwide. Free cold-chain delivery on orders over £65. Refrigerate immediately on arrival.
My doctor recommended the De Simone Formulation — is this right?
CDS22-formula is the current brand for the De Simone Formulation, which is referenced in ECCO and American College of Gastroenterology clinical guidelines. Always confirm any product change with your clinical team before switching.
Where can I see the full ingredients and product details?
Full ingredients, allergens, usage guidance, and product information are on the product page at probiotic.co.uk. Please review all product details before purchasing, particularly if you are under clinical supervision or have known allergies.
Get the original formula.
Not the copy.
CDS22-formula is the only product in the UK still carrying the original De Simone Formulation. Cold-chain DPD. Next-day UK delivery. From £14.99 per pack.
Shop CDS22-formula →4.9★ Trustpilot · 161 verified reviews · Official UK distributor · Secure checkout
Free cold-chain delivery over £65 · Next-day DPD
Free cold-chain delivery over £65 · Next-day DPD