Looking for VSL#3? The Original Formula is Now CDS22-formula |

Looking for VSL#3? The Original Formula is Now CDS22-formula | Probiotic.co.uk
De Simone Formulation brand history — the original formula was in VSL#3, then became Vivomixx, now is CDS22-formula. VSL#3 today does not contain the original formulation.
Shop CDS22-formula — the original formula →

From £14.99 per pack · Free cold-chain delivery over £65 · Next-day UK

Cold-chain DPD — live cultures protected door to door
Next-day UK delivery available
Official UK & Ireland distributor
4.9/5 · 161 verified Trustpilot reviews
What actually happened

Three facts. No fluff.

Fact 01

VSL#3 originally contained the De Simone Formulation (DSF) — 8 specific bacterial strains, 450 billion CFU. It is one of the most clinically studied probiotic formulations, with 80+ peer-reviewed studies and 200+ scientific publications.

Fact 02

In 2016 the brand changed to Vivomixx. It later changed again to CDS22-formula. The formulation itself — the strains, the CFU, the science — remained unchanged throughout.

Fact 03

VSL#3 today does not contain the original formula. CDS22-formula is the only product currently available in the UK still using the original De Simone Formulation.

If you were taking VSL#3 for a clinical reason and want the same formulation, CDS22-formula is what you are looking for. The brand changed. The formula did not.

Brand history notice Previously marketed as Vivomixx® (owned by Mendes SA) until 2025 & VSL#3® (owned by Actial Srl) prior to that. No affiliation to these brands exists. CDS22-formula is an independent product distributed in the UK & Ireland by Probiotic.co.uk.

Get the original formula.
Not the copy.

Shop CDS22-formula →

From £14.99 per pack · Free cold-chain delivery over £65 · Next-day UK

450B CFU per sachet — original DSF
8 Original De Simone strains
❄️ Cold-chain DPD delivery
🇬🇧 Official UK distributor
❄️ Free cold-chain delivery on orders over £65
3 packs: £2.65/pack shipping · 4+ packs: free shipping
Grab deal now →

Secure checkout · Visa · Mastercard · Apple Pay · Google Pay

VSL#3 users who found the original formula

What VSL#3 customers say after switching

Trustpilot — Probiotic.co.uk rated Excellent 4.9 out of 5
4.9 / 5 · Excellent
★★★★★
161 verified reviews
★★★★★

"I was introduced to De Simone's VSL#3 two years ago after a bad digestion issue. A consultant suggested it. Moved to Vivomixx as couldn't get in UK. Saw it is now available under De Simone's own label. Very pleased."

Maureen Ruddy
Nov 2025
Verified
★★★★★

"Great to see Irish market offering the best range of supplements and my trusted Probiotics CDS22 aka VSL#3. I was disappointed that I couldn't buy VSL#3 from my regular UK supplier."

Petru A
Trustpilot
Verified
★★★★★

"I used Vivomixx for quite some time then moved to CDS22-formula. This is an excellent probiotic. I would certainly recommend this product."

Verified customer
Trustpilot
Verified
Read all 161 reviews on Trustpilot → Shop CDS22-formula →
Cold-chain delivery

Live cultures. Protected all the way.

Packed cold in LancashireTemperature-controlled from the moment your order is picked at our UK facility — Matrix Park, Chorley, PR7 7NB.
Shipped refrigerated via DPDCold-chain throughout transit. Next-day delivery available nationwide. Free over £65.
Refrigerate on arrivalTransfer to your fridge immediately. Live cultures must be kept cold to maintain viability.
Full cold-chain details: probiotic.co.uk/pages/cds22-delivery-information
Shop CDS22-formula →
Clinical heritage

One of the most clinically studied probiotic formulations.

80+Clinical studies on this exact formulation
200+Scientific publications
450BCFU per sachet
4.9★161 Trustpilot reviews
  • The formulation's lineage is addressed in a 2023 European Crohn's and Colitis Organisation (ECCO) statement, which clarified that post-2016 VSL#3 no longer contains the original De Simone Formulation
  • Named in the American Gastroenterological Association (AGA) 2024 pouchitis guideline (Barnes et al., Gastroenterology 2024;166(1):59-85, PMID 38128971)
  • NHS Patient Access Programme available via Probiotic.co.uk
  • Exclusive UK & Ireland distributor — Probiotic.co.uk, Chorley, Lancashire
Common questions

VSL#3 searchers ask these

Yes. The original De Simone Formulation that was inside VSL#3 is now sold as CDS22-formula. VSL#3 today has been reformulated and no longer contains the original strains. CDS22-formula is the only product in the UK still carrying the original formulation, available now with cold-chain next-day delivery.
No. VSL#3 has been reformulated and no longer contains the original De Simone Formulation strains. The original formulation moved to Vivomixx in 2016 and then to CDS22-formula. CDS22-formula is the only product currently available in the UK that contains the original De Simone Formulation.
The De Simone Formulation (DSF) is a specific 8-strain probiotic formulation developed by Professor Claudio De Simone. It has been the subject of more than 80 peer-reviewed clinical studies. The formulation is named in the American Gastroenterological Association (AGA) 2024 pouchitis guideline (Barnes et al., PMID 38128971), and its lineage is addressed in a 2023 ECCO statement. CDS22-formula contains this exact formulation.
VSL#3 originally contained the De Simone Formulation — 8 specific bacterial strains at 450 billion CFU. VSL#3 has since been reformulated and no longer contains those original strains. CDS22-formula contains the original De Simone Formulation — the same 8 strains, 450 billion CFU, 12 sachets per pack.
CDS22-formula contains live bacteria and must be refrigerated. We ship cold-chain via DPD from our temperature-controlled facility in Lancashire. Next-day delivery available nationwide. Free cold-chain delivery on orders over £65. Refrigerate immediately on arrival.
CDS22-formula is the current brand for the De Simone Formulation, which is named in the American Gastroenterological Association (AGA) 2024 pouchitis guideline and a 2023 ECCO statement on the formulation's lineage. Always confirm any product change with your clinical team before switching.
Full ingredients, allergens, usage guidance, and product information are on the product page at probiotic.co.uk. Please review all product details before purchasing, particularly if you are under clinical supervision or have known allergies.
Brand history notice Previously marketed as Vivomixx® (owned by Mendes SA) until 2025 & VSL#3® (owned by Actial Srl) prior to that. No affiliation to these brands exists. CDS22-formula is an independent product distributed in the UK & Ireland by Probiotic.co.uk.

CDS22-formula is a probiotic food supplement and is not a medicine. This page is for product identification and purchasing purposes only and does not constitute medical advice. Food supplements are not intended to diagnose, treat, cure, or prevent any disease. If you are under clinical supervision, confirm any product change with your healthcare team before switching. Clinical studies referenced are published peer-reviewed research on the De Simone Formulation and are cited factually. Probiotic.co.uk is regulated under UK food supplement legislation. Customer reviews sourced from Trustpilot and reproduced with permission under a paid Trustpilot business subscription.

Tracked UK Shipping

Next-day delivery via Royal Mail 24 or DPD. Cold-chain protected to your door. We ship to all of the UK, including NI

Expert Email Support

Our specialist team offers rapid response email support 5 days a week for your peace of mind.

Secure & Encrypted

Fully PCI-compliant checkout with industry-leading SSL encryption for 100% safe transactions.

Specialist UK Facility

Dispatched from our temperature-controlled hub: Matrix Park, Western Avenue, Chorley, PR7 7NB.
Copyright © Probiotic.co.uk 2026
American Express Apple Pay Diners Club Discover Google Pay Maestro Mastercard Shop Pay Union Pay USDC Visa