★★★★★
"Everything arrived packed with care, cooled as probiotics should. The new CDS22-formula is perfect, just like Vivomixx was. They perform the same function, so they should be the same formula as claimed."
Looking for Vivomixx? It's Now CDS22-formula...
📦 Vivomixx customers — you are in the right place
Looking for Vivomixx?
It's now called CDS22-formula
The De Simone Formulation has a new name. The formula and the 8 live cultures are the same. In stock now with cold-chain next-day UK delivery.
Order CDS22-formula →
From £14.99 per pack · Free cold-chain delivery over £65 · Next-day UK
Cold-chain DPD — live cultures protected door to door
Next-day UK delivery available
Official UK & Ireland distributor
NHS Patient Access Programme available
Vivomixx customers who switched
What real customers say about making the switch
4.9
/ 5 · Excellent
★★★★★
161 verified reviews
★★★★★
"I used Vivomixx for quite some time then moved to CDS22-formula. This is an excellent probiotic. I have gut issues — by using CDS22 it helps me a lot. I would certainly recommend this product."
★★★★★
"I used to have Vivomixx & as that wasn't available for a while so I changed to CDS22 & it appears to be as good & as claimed. The Probiotic website is easy to use & the order was delivered with a frozen ice pack."
★★★★★
"I'm delighted to find a new supplier for the original De Simone Formulation, now that Vivomixx don't sell it. The fact that probiotic.co.uk has an NHS Patient Access Programme adds further credibility to their offering."
★★★★★
"I was introduced to De Simone's formula two years ago after a bad digestion issue — a consultant suggested it. Moved to Vivomixx as couldn't get it in UK. Saw it is now available under De Simone's own label. Very pleased."
The formulation story
Same formula. Different name. Three times.
The De Simone Formulation has carried three brand names since 2003. The 8 bacterial strains and 450 billion CFU per sachet have never changed.
The same De Simone Formulation. Three brand names across 20+ years.
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Before 2016 — the De Simone Formulation was sold in the EU and UK under the first brand name
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2016–2024 — rebranded as Vivomixx in Europe and the UK
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2024–25 onwards — now CDS22-formula in UK & EU. Same formula.
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8 strains · 450 billion CFU · formulation unchanged throughout
Taking Vivomixx on clinical advice?
CDS22-formula is the current product in the same formulation lineage. Always confirm any product change with your healthcare team before switching.
Brand history notice
Previously marketed as Vivomixx® (owned by Mendes SA) until 2025 & VSL#3® (owned by Actial Srl) prior to that. No affiliation to these brands exists. CDS22-formula is an independent product distributed in the UK & Ireland by Probiotic.co.uk.
Continuity context
What changed. What didn't.
| Factor | CDS22-formula |
|---|---|
| 8 bacterial strains | Original De Simone Formulation — unchanged |
| CFU per sachet | 450 billion — unchanged |
| Sachets per pack | 12 sachets (Vivomixx was 10 — more per pack) |
| Clinical research base | Same formulation as 80+ published studies |
| Cold-chain required | Yes — shipped refrigerated via DPD |
| UK availability | In stock now at Probiotic.co.uk |
| What changed | Brand name only |
Order now — UK stock
CDS22-formula — choose your pack
12 sachets per pack · 450 billion CFU · Cold-chain DPD delivery
❄️ Free cold-chain delivery on orders over £65
3 packs: £2.65/pack shipping · 4+ packs: free shipping
3 packs: £2.65/pack shipping · 4+ packs: free shipping
Buy 2 — save £2.00
24 sachets total
£39.00
£37.00
Most popular
Buy 3 — save £8.00
36 sachets · £16.83/pack · free delivery
£58.50
£50.50
Buy 4 — save £15.50
48 sachets · free delivery
£78.00
£62.50
Buy 5 — save £23.00
60 sachets · free delivery
£97.50
£74.50
Buy 6 — save £27.01
72 sachets · £14.99/pack · free delivery
£117.00
£89.99
Secure checkout · Visa · Mastercard · Apple Pay · Google Pay
Cold-chain delivery
Live cultures. Protected all the way to your door.
Packed cold in Lancashire
Temperature-controlled from the moment your order is picked at our UK facility — Matrix Park, Chorley, PR7 7NB.
Shipped refrigerated via DPD
Cold-chain throughout transit. Next-day delivery available nationwide. Free cold-chain delivery on orders over £65.
Refrigerate on arrival
Transfer to your fridge immediately on delivery. Live cultures must be kept refrigerated to maintain viability.
Full cold-chain and delivery details: probiotic.co.uk/pages/cds22-delivery-information
Order CDS22-formula →
Clinical heritage
The most researched high-potency probiotic formulation in the UK.
80+
Clinical studies on this exact formulation
200+
Scientific publications
450B
CFU per sachet
4.9★
161 Trustpilot reviews
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Referenced in ECCO guidelines for Inflammatory Bowel Disease management (ECCO News, 2023)
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Referenced in American College of Gastroenterology guidance for pouchitis (Olleik et al., Gastroenterology, Vol. 164, No. 6, 2023)
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NHS Patient Access Programme available via Probiotic.co.uk
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Exclusive UK & Ireland distributor — Probiotic.co.uk
Common questions
Before you order
I searched for Vivomixx — am I in the right place?
Yes. CDS22-formula is the current brand for the De Simone Formulation in the UK. If you were buying Vivomixx, this is the current product in the same formulation lineage — available now with cold-chain next-day delivery from Probiotic.co.uk.
Is CDS22-formula the same as the Vivomixx I was taking?
CDS22-formula carries the same De Simone Formulation — 8 bacterial strains and 450 billion CFU per sachet. The brand name changed. The pack contains 12 sachets compared to Vivomixx's 10 sachets, at the same price point — more per pack.
Why does CDS22-formula have 12 sachets when Vivomixx had 10?
CDS22-formula packs contain 12 sachets versus Vivomixx's 10-sachet packs at the same price point — you get more sachets per pack. Bundle pricing brings the cost as low as £14.99 per 12-sachet pack when you order 6 packs.
Is Vivomixx still available in the UK?
Vivomixx is not currently available through major UK stockists. CDS22-formula is the current product in this formulation lineage available to purchase in the UK, shipped cold-chain to your door from our Lancashire facility.
How is CDS22-formula stored and delivered?
CDS22-formula contains live bacteria and must be refrigerated. We ship cold-chain via DPD from our temperature-controlled facility in Lancashire. Next-day delivery is available nationwide. Free cold-chain delivery on orders over £65. Refrigerate immediately on arrival.
My gastroenterologist recommended this formulation — is this the right product?
CDS22-formula is the current brand for the De Simone Formulation, which is referenced in ECCO and American College of Gastroenterology clinical guidelines. Always confirm any product change with your clinical team before switching.
Where can I see the full ingredients and product details?
Full ingredients, allergens, usage guidance, and product information are on the product page at probiotic.co.uk. Please review all product details before purchasing, particularly if you are under clinical supervision or have known allergies.
The formula hasn't changed.
Only the name has.
Order CDS22-formula today. Cold-chain DPD. Next-day UK delivery available. From £14.99 per pack. Free delivery on orders over £65.
Order CDS22-formula →
4.9★ Trustpilot · 161 verified reviews · Official UK distributor · Secure checkout