CDS22-formula vs VSL#3: Original De Simone Formula Comparison

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Looking for VSL#3? Here’s the Original Formula
It Was Based On.

CDS22-formula is the original De Simone Formulation — the clinically validated blend behind the research that made VSL#3 popular.

Same original De Simone Formulation used in the clinical research

Rated 4.8★ on UK Trustpilot (100+ Verified UK customers)

Cold-chain packed and shipped for maximum potency

Certified by Prof. Claudio De Simone — inventor of the original formula and creator of VSL#3

12 sachets per box (20% more value than VSL#3’s old 10-sachet format)

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CDS22-formula, the world’s most powerful probiotic. This groundbreaking formulation is the original 8-strain, 450-billion CFU probiotic blend. Previously Marketed as Vivomixx* (owned by Mendes SA) until 2025 & VSL#3* (owned by Actial Srl) prior to that. No affiliation to these brands exists.

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 The Simple Truth (in 10 Seconds)
VSL#3 or CDS22? There’s Only One Original De Simone Formulation.

Trusted by clinicians, validated by clinical studies, and certified by Professor Claudio De Simone — the inventor himself.

If you previously used VSL#3, here is what you should know:

  • CDS22-formula uses the original, patented De Simone Formulation.
  • VSL#3 changed its recipe completely in 2016 and no longer contains the original composition from the clinical trials.
  • Professor Claudio De Simone publicly confirmed that only CDS22 (and Visbiome in the US) use his authentic formula.
  • CDS22 contains 12 sachets per box, not 10 like the old VSL#3 format.
  • Cold-chain packed and shipped next-day for maximum viability.

📌 If you want the probiotic that matches the clinical data, this is the one.

Switch to CDS22-formula Today

Healthy heart

Mental health

Healthy gut

Healthy liver

Healthy skin

"Delighted to have CDS22 back in my life. Was using the only one available until I saw it was back on sale in UK.
It has remedied my gut issues. Take half a sachet every morning and gut feels beat it ever has.
Thoroughly recommend. I bore people about how good this probiotic is for people with IBS.” Maureen Ruddy Trustpilot Nov 3rd

Emily / Customer

CDS22-formula vs VSL#3  

CDS22-formula

Original De Simone Formulation

Backed by 80+ Peer-Reviewed Clinical Trials**

Authored by the Inventor Himself

Proven Clinical Continuity

Manufactured Under Original Pharmacutical Standards

Exclusive UK & Ireland Availability

VSL#3

No Longer the Original Formulation

No Clinical Trial Evidence for Reformulated Version

Reformulated Without the Inventor’s Involvement

Previously Found Liable for Misrepresentation

Switch Not Communicated Clearly to Consumers

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**80+ Peer Reviewed Clinical Trials

Free Cold Chain Shipping included for orders over £60  

What VSL#3 Used to Be & What It Isn’t Anymore

“If You Used VSL#3 Before, Read This”

 

People who used VSL#3 between 2002 and 2015 were taking the De Simone Formulation, invented and patented by Professor Claudio De Simone.

 

In 2016, the formula was replaced after a legal dispute.

The original formula left VSL#3 and became CDS22-formula in the UK & Europe.

 

That’s why many long-term users search for:

• “Why does VSL#3 feel different now?”

• “Is VSL#3 the same as before?”

• “Where can I buy the original De Simone formula?”

 

📌 Answer: the original formulation is now sold as CDS22-formula.

 

CDS22-formula (Original De Simone Formulation)

 

1. Original De Simone Formulation

The same clinically validated formulation used in all published VSL#3 research before 2016.

 

2. Backed by 80+ Peer-Reviewed Clinical Trials

Every trial behind VSL#3’s reputation was conducted using this original formulation.

 

3. Authored by the Inventor Himself

Created and certified by Prof. Claudio De Simone — the originator and developer of the formula sold for years as VSL#3.

 

4. Proven Clinical Continuity

No reformulation. No changes. Same strain mix, same ratios, same evidence base.

 

5. Manufactured Under Original Standards

European production with full cold-chain handling as referenced in the clinical file.

 

6. Exclusive UK & Ireland Availability

The original formulation is now sold exclusively as CDS22-formula in the UK and Ireland.

 

 

 

✘ 

VSL#3 (Post-2016 Reformulated Version)

 

 

1. No Longer the Original Formulation

Court-confirmed that post-2016 VSL#3 is not the original De Simone Formulation.

 

2. Class-Action Lawsuit in the U.S.

A federal judge certified a class action alleging the formula change misled consumers.

 

3. Previously Found Liable for Misrepresentation

A U.S. jury awarded $18M in damages for falsely implying continuity of the original formula.

 

4. Reformulated Without the Inventor’s Involvement

Prof. De Simone had no role in the new VSL#3 formula.

 

5. Switch Not Communicated Clearly to Consumers

The court found customers believed they were still buying the original formulation when they were not.

Why CDS22-formula Is the Smarter Choice for VSL#3 Users

A quick breakdown of the key facts that matter most when you’re choosing between VSL#3 and the clinically validated original De Simone formulation.

Your Daily Essentials

450B CFU Clinically Validated Formula

8 High-Strength Proven Multi-Strain Blend

12-Sachet Value Box - 20% More

4.8★ Verifired UK Rating

  100% Certified   

Professor Claudio De Simone’s Certification 

Certified by the Inventor – No Other Product in the UK Has This
 

CDS22-formula is produced under the supervision and scientific guidance of Professor Claudio De Simone, creator of the De Simone Formulation with over 200 scientific publications** behind it.

 

✖️He does not endorse VSL#3.

✖️He does not supply VSL#3.

✖️He does not acknowledge VSL#3 as containing his formulation.

 

✅ Only CDS22-formula (EU) and Visbiome (US) are authorised.

**200+ Scientific Publications - Click Here

Why CDS22 Has 12 Sachets? 

 

Most people remember VSL#3 sachets coming in 10-packs.

 

CDS22-formula contains 12 sachets at the same RRP level that VSL#3 historically sold at.

 

This gives:

20% more sachets

Lower cost per dose

Better long-term value

 

📌 VSL#3 users switching to CDS22 immediately notice the value difference.

Over 100 Five Star Reviews!

Cold-Chain Packaging & Next-Day Delivery

Your CDS22 order ships with:
✅ Cold-chain packaging - 
✅ An ice pack - (Easy-Chill Industry Leader)
✅ 24-hour Royal Mail Tracked delivery
✅ Room-temperature stability for 7 days, confirmed by the manufacturer
 
❎ No extra charge.
❎ No hidden fees.
☑️ Just proper handling for a sensitive, high-potency
formulation.

"Arrived cold. Well packaged."

Mark S / TrustPilot Dec 2nd 2025

Grab The Deal 

Free Cold Chain Shipping for orders over £60 

Marina T. - TrustPilot Review - November 10th 2025 

Verified Buyer

Best out there, Google it!

I’ve been using De Simone probiotics for the doctor-recommended three-month course to help restore my balance after pregnancy, and this is already my second order. These are genuinely the best probiotics I’ve ever tried—and the deals make it even sweeter. A loyal customer for life. ❤️❤️.”

   Multibuy Offer   

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Buy 4 Boxes

£19.50/box of 12 sachets

£78.00

£62.50

Title

FIRST TIME PURCHASE INCLUDES:

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£7.95

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£85.95

£62.50

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Trusted daily by happy users 

Helping IBS

"Great Experience

Delivery arrived quickly and my gut is starting to feel better already. Got severe IBS so I'm in it for the long haul."

WB - Trustpilot 

Verified Buyer

Good Value

"Prompt delivery, good value for money

Prompt delivery, you won’t find a higher strength probiotic than the CDS22-Formula, excellent value for money."

Laurence Fisher - Trustpilot 

Verified Buyer

Excellent Service

"A helpful team and excellent service

Products are delivered promptly as promised"

Sarah L.

Verified Buyer

   CDS22-formula FAQs   

Frequently Asked Questions

Is this the same as the old VSL#3 I used years ago?

Yes. CDS22-formula uses the original De Simone Formulation from the clinical trials before VSL#3 changed its recipe.

Why did VSL#3 change?

After 2016, the formulation rights changed. The inventor did not supply VSL#3 anymore.

Is CDS22 safe in transit?

Yes. It is shelf-stable for 7 days at room temperature and shipped with cold-chain packaging.

How many sachets are in each box?

12 sachets. VSL#3 traditionally had 10.

Are you the official UK distributor?

Yes. Probiotic.co.uk supplies CDS22-formula directly from the authorised EU producer.

Do you sell the Capsules Version as well?

Yes, they are availible in the larger 20 capsule pack.

100% Happiness Guarantee

 

VSL#3 post-2016 no longer matches the original formulation


CDS22-formula is the certified medically researched high strength probiotic.

 

✅ That’s why clinicians, nutritionists, and informed customers have switched.

1500+

UK & EU Happy Customers

4.8 Stars rating

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