CDS22-Formula | Original De Simone Formulation UK Probiotic (450 Billion CFU) | Larger 12 Sachet Pack
CDS22-Formula | Original De Simone Formulation UK Probiotic (450 Billion CFU) | Larger 12 Sachet Pack
CDS22-formula is the original 8-strain De Simone Formulation, supplied as 12 sachets, with 450 billion live cultures (CFU) per sachet. It is the formulation developed by Professor Claudio De Simone and carries the De Simone "Approved" authenticity seal, identifying it as the genuine formulation.
It is the same formulation sold under the VSL#3 brand until 2016 and the Vivomixx brand in the EU and UK until 2025. The identity is carried by the eight strains and their NCIMB deposit codes, not by the brand name. Refrigerated and cold-chain dispatched across the UK. £19.95 per pack.
At a glance
- Formulation: the original 8-strain De Simone Formulation (sold as VSL#3 until 2016, Vivomixx until 2025)
- Live bacteria: 450 billion CFU per sachet, across 8 NCIMB-identified strains
- Format: 12 sachets (4.4g each) · powder to mix into a cool drink or yogurt
- Authenticity: carries the De Simone "Approved" seal · gluten-free
- Research: an extensive published scientific literature (full reference list linked below)
- Storage: refrigerate +2°C to +8°C (stable to 25°C for up to 7 days)
- Price & dispatch: £19.95 inc. VAT · cold-chain shipped across the UK
VSL#3 to Vivomixx to CDS22-formula: the lineage explained
If you previously bought VSL#3 or Vivomixx in the UK and are looking for the same product, here is how the names connect. The formulation is the constant; only the brand names changed.
| Period | Brand name | Contains the De Simone Formulation? |
|---|---|---|
| Until 2016 | VSL#3 | Yes — most pre-2016 "VSL#3" references relate to this |
| After 2016 | VSL#3 (current) | No — per the ECCO official statement |
| 2016 – 2025 | Vivomixx (EU/UK) | Yes — same 8-strain formulation |
| Now | CDS22-formula | Yes — original 8 strains, 450bn CFU |
Because the brand name and the formulation diverged in 2016, identity is best matched by the strain list (below), not by the brand name alone. For the full strain-by-strain identity reference and the source documents, see the De Simone Formulation UK reference guide. If you previously bought VSL#3, see VSL#3 alternative UK; for the Vivomixx change, see what happened to Vivomixx.
An extensively documented formulation
The De Simone Formulation has an extensive published scientific literature. The full reference list is maintained here: the De Simone Formulation scientific publications and clinical studies bibliography. These references describe the formulation as it appears in the scientific literature; they are provided for transparency and are not a statement that this food supplement treats, prevents or cures any condition.
The 8 strains in CDS22-formula (per sachet)
Each sachet delivers 450 billion live cultures across 8 strains, identified by their NCIMB strain codes so they can be verified against the published literature:
| Strain | NCIMB code | Per sachet |
|---|---|---|
| Streptococcus thermophilus | NCIMB 30438 | 226 billion |
| Lactobacillus acidophilus | NCIMB 30442 | 38 billion |
| Lactobacillus plantarum | NCIMB 30437 | 38 billion |
| Lactobacillus paracasei | NCIMB 30439 | 38 billion |
| Lactobacillus helveticus | NCIMB 30440 | 38 billion |
| Bifidobacterium breve | NCIMB 30441 | 24 billion |
| Bifidobacterium animalis subsp. lactis | NCIMB 30435 | 24 billion |
| Bifidobacterium animalis subsp. lactis | NCIMB 30436 | 24 billion |
| Total live cultures per sachet | 450 billion | |
Older clinical literature and the US Visbiome product list these organisms under DSM codes (e.g. DSM 24731–24737). They are the same formulation; the current UK CDS22-formula label uses the NCIMB designations above.
Why buy from Probiotic.co.uk
- The genuine De Simone Formulation, carrying the De Simone "Approved" authenticity seal
- Cold-chain handled: shipped refrigerated from the manufacturer (EOS2021 S.r.l., Italy) to our temperature-controlled UK facility, then dispatched cold — so the live count on the label is the count you receive
- Appointed by the manufacturer (EOS2021 S.r.l.) as the sole authorised UK and Ireland distributor of CDS22-formula
- 8 strains, each identified by its NCIMB deposit code for verification
- UK dispatch — no import or customs charges
How we deliver a refrigerated probiotic, safely
A common question: will a refrigerated product survive shipping? CDS22-formula stays stable at room temperature (up to 25°C) for up to 7 days per the manufacturer's storage leaflet, so a normal 24 to 48 hour delivery does not affect the live cultures, even if an ice pack has melted on arrival. We still ice-pack and foil-line every order anyway:
- Easi-Chill coolant packs and insulated foil liners — up to 73 hours of chilled protection in transit
- Dispatched Monday to Thursday only, so orders don't sit in a depot over the weekend
- Royal Mail Tracked 24 or DPD Premium Tracked
- Refrigerate on arrival to maintain the live count to the best-before date
Supply, bundles and subscription
A 12-sachet pack is about 1 to 2 weeks' supply at 1 to 2 sachets a day. For continuous use, the multi-pack bundle and the monthly subscription give a lower price per pack, and CDS22-formula keeps for 18 months refrigerated, so stocking up won't go to waste.
Other formats and the full range
- CDS22-formula 112 billion capsules (20-pack) — same formulation, capsule format, lower count per serving
- CDS22-formula Infant Drops — for babies and young children
- All CDS22-formula products — full range
How to use
- Adults and children 7+: 1 to 2 sachets per day
- Children 3 to 6 years: up to half a sachet per day
- Open and mix into a cool, non-fizzy drink, yogurt or fruit juice; consume immediately. Do not add to hot liquids
- Do not exceed the recommended daily dose
Storage
- Store in the refrigerator (+2°C to +8°C) to maintain the live cultures
- Can be kept at room temperature (up to 25°C) for up to one week
- Avoid temperatures above 25°C · 18-month shelf life from manufacture when refrigerated
Product details
Food supplement with 450 billion live cultures per sachet. Format: 12 sachets of 4.4g (52.8g total). Made by EOS2021 S.r.l., Italy. Price £19.95 inc. 20% VAT.
Ingredients
Maltose, mixture of lactic ferments (Streptococcus thermophilus NCIMB 30438, Bifidobacterium breve NCIMB 30441, Bifidobacterium animalis subsp. lactis NCIMB 30435, Bifidobacterium animalis subsp. lactis NCIMB 30436, Lactobacillus acidophilus NCIMB 30442, Lactobacillus plantarum NCIMB 30437, Lactobacillus paracasei NCIMB 30439, Lactobacillus helveticus NCIMB 30440). Gluten-free.
The live cell count refers to the product correctly stored in intact packaging at refrigerated temperature (+2°C to +8°C) until the best-before date.
Nutritional declaration
| Per 100g | Per sachet (4.4g) | |
|---|---|---|
| Energy | 1554 kJ / 366 kcal | 68.37 kJ / 16.10 kcal |
| Fat | 0.5 g | 0.02 g |
| of which saturates | 0.1 g | 0.00 g |
| Carbohydrate | 80 g | 3.52 g |
| of which sugars | 63 g | 2.77 g |
| Protein | 10 g | 0.44 g |
| Salt | 0.28 g | 0.01 g |
Frequently asked questions
What is the De Simone Formulation?
The De Simone Formulation is an 8-strain live bacteria mixture developed by Professor Claudio De Simone. It was sold under the VSL#3 brand until 2016, then under the Vivomixx brand in the EU and UK and the Visbiome brand in the US and Canada, and is supplied in the EU and UK today as CDS22-formula. The strains are identified by their NCIMB deposit codes.
Is CDS22-formula the same as Vivomixx?
CDS22-formula carries the same 8-strain De Simone Formulation, identified by the NCIMB strain codes on the label, that was sold under the Vivomixx brand in the EU and UK until 2025. Identity is best confirmed by the strain list rather than the brand name. Vivomixx is a registered trademark of Mendes SA; CDS22-formula is not affiliated with it.
Is CDS22-formula the same as VSL#3?
CDS22-formula contains the original De Simone Formulation, which was sold under the VSL#3 brand until 2016. Per the ECCO official statement, the product sold as VSL#3 after 2016 no longer contains the De Simone Formulation, so most pre-2016 VSL#3 references relate to the formulation now supplied as CDS22-formula. VSL#3 is a registered trademark of VSL Pharmaceuticals Inc. and Actial S.r.l.; CDS22-formula is not affiliated with it.
Who is the official UK distributor of CDS22-formula?
Probiotic.co.uk is the sole authorised UK and Ireland distributor of CDS22-formula, appointed by the manufacturer EOS2021 S.r.l. On the manufacturer's website, cds22.com, selecting the United Kingdom or Ireland directs customers to Probiotic.co.uk as the authorised distributor for those markets. Buying from the authorised distributor is how you confirm you are receiving the genuine De Simone Formulation, cold-chain handled.
How many strains and how much CFU does CDS22-formula contain?
Each sachet contains 8 strains delivering 450 billion live cultures (CFU): Streptococcus thermophilus NCIMB 30438 (226 billion), Lactobacillus acidophilus NCIMB 30442 (38 billion), Lactobacillus plantarum NCIMB 30437 (38 billion), Lactobacillus paracasei NCIMB 30439 (38 billion), Lactobacillus helveticus NCIMB 30440 (38 billion), Bifidobacterium breve NCIMB 30441 (24 billion), and Bifidobacterium animalis subsp. lactis NCIMB 30435 and NCIMB 30436 (24 billion each).
What is the difference between the 450 billion sachets and the 112 billion capsules?
Both are the same 8-strain De Simone Formulation with the same NCIMB strains. The difference is the live count per serving and the format: this product is 450 billion CFU per sachet in a powder you mix into a cool drink or yogurt, while the capsule product is 112 billion CFU per vegetable capsule. The choice is about format preference and the count you want per serving.
Does CDS22-formula need to be refrigerated?
Yes. CDS22-formula is a refrigerated product and should be stored at +2°C to +8°C to maintain the live cultures, with an 18-month shelf life from manufacture when kept refrigerated. It can be kept at room temperature up to 25°C for up to one week. Probiotic.co.uk dispatches it cold-chain across the UK to preserve the live count.
Will CDS22-formula survive delivery if the ice pack melts?
Yes. CDS22-formula stays stable at room temperature up to 25°C for up to 7 days per the manufacturer's storage leaflet, so a normal 24 to 48 hour delivery does not affect the live cultures even if the ice pack has melted on arrival. We still ice-pack and foil-line every order for up to 73 hours of chilled protection, and dispatch Monday to Thursday. Refrigerate the product on arrival.
Is CDS22-formula a medicine, and is it legal in the UK?
CDS22-formula is sold legally in the UK as a food supplement. It is not a medicine and is not intended to diagnose, treat, cure or prevent any disease. No prescription is required.
How do I take CDS22-formula?
Adults and children aged 7 and over take 1 to 2 sachets per day; children aged 3 to 6 take up to half a sachet per day. Mix the contents into a cool, non-fizzy drink, yogurt or fruit juice and consume immediately. Do not add to hot liquids. Do not exceed the recommended daily dose.
Download the Patient Information Sheet (PDF) · CDS22-formula FAQs
Product details: CDS22-formula · 12 sachets (4.4g) · 450 billion CFU per sachet · 8 strains with NCIMB codes · the original De Simone Formulation · De Simone "Approved" seal · sole authorised UK & Ireland distributor · £19.95 inc. 20% VAT.
VSL#3® is a registered trademark of VSL Pharmaceuticals Inc. and Actial S.r.l. Vivomixx® is a registered trademark of Mendes SA. Visbiome® is a registered trademark of ExeGi Pharma. CDS22-formula is manufactured by EOS2021 S.r.l. and is not affiliated with, endorsed by, or distributed by the VSL#3, Vivomixx or Visbiome trademark holders. Historical brand names are used for identification and factual continuity only.