UK Probiotics Specialists for the Original De Simone Formulation
High-strength probiotics and clinically established gut health protocols
Clinically Backed. UK Delivered.
The Original De Simone Probiotic Proven Across the UK
Trusted in the UK for Gut Health That Works
❄️ Cold Chain Delivery ❄️
We’re UK-based, with next-day dispatch from our Lancashire facility. Our bestselling CDS22-formula is a high-strength, multi-strain probiotic trusted to ease bloating, support digestion, improve IBS symptoms, and boost immune health.
Previously known as Vivomixx & VSL#3 – this is the original De Simone Formulation, relied on daily by thousands across the UK.
CDS22-Formula: The Original 450 Billion CFU 8-Strain Formulation
CDS22-Formula | Original De Simone Formulation UK Probiotic (450 Billion CFU) | Larger 12 Sachet Pack
£19.50
Regular price
£23.95
CDS22-formula | The Original De Simone Formulation UK Probiotic (112B CFU) | 20 Cap Pack
£17.90
CDS22-formula Probiotic Infant Drops - Pack of 2 Bottles
£13.50
Regular price
£14.95
Clinical Heritage & About Probiotic.co.uk
A Statement from the CEO: Restoring Clarity to Probiotic Science
At Probiotic.co.uk, our mission is to ensure that UK patients and clinicians have access to the specific high-strength formulation that built the foundation of probiotic research. For decades, one specific 8-strain blend—the De Simone Formulation (DSF)—has been the global gold standard. However, shifts in branding have created significant confusion in the market.
The Official Clinical Position:
- The ECCO Clarification: The European Crohn’s and Colitis Organisation (ECCO) officially stated in 2023 that clinical guideline references for ulcerative colitis and pouchitis apply exclusively to the original De Simone Formulation, noting that products sold under the brand VSL#3 after 2016 no longer contain this original blend.
- The Evidence: A 2024 meta-analysis in the Journal of Crohn’s and Colitis affirms that the De Simone Formulation (now available as CDS22-formula) remains the most effective multi-strain probiotic for maintaining remission in complex gut conditions.
We do not just sell 'probiotics'; we provide the original science. Every sachet of CDS22-formula we deliver via our guaranteed cold-chain is the identical, inventor-certified blend backed by over 200 peer-reviewed scientific studies.
Darren Grant
CEO, Probiotic.co.uk & Probiotic.ie
Clinically Studied. Expert Selected.
Premium Supplements Backed by Science - Loved in the UK
Explore our expert-selected range of high-quality supplements, trusted by UK customers seeking natural support for energy, focus, mood, and metabolic health. From clinically studied Berberine, to calming Ashwagandha, to brain-boosting Lion’s Mane Mushroom, each product is chosen for its purity, potency, and proven benefits. Whether you’re managing stress, blood sugar, or brain fog, you’ll find clean, effective formulas designed to help you feel your best.
Top 10 Bestselling Supplements UK | @ Probiotic.co.uk
Discover the UK’s top 10 supplements trusted for gut health, stress relief, brain clarity, and immune support. From our powerful CDS22-formula probiotic to bestselling Berberine, Ashwagandha, and Lion’s Mane Mushroom, these customer favourites deliver real results — naturally.
Clean ingredients. Fast UK delivery. Backed by science & loved by thousands.
CDS22-Formula | Original De Simone Formulation UK Probiotic (450 Billion CFU) | Larger 12 Sachet Pack
£19.50
Regular price
£23.95
Swanson Berberine 400 mg 60 Caps
£17.95
Regular price
£24.95
Swanson Lion's Mane Mushroom - Full Spectrum 500mg - 60 caps
£8.95
Regular price
£10.95
Swanson Ashwagandha 450mg 100 Caps
£10.95
Regular price
£13.95
Sleep & Stress Support – Calm Your Mind, Rest Your Body
Struggling with stress, anxious thoughts, or sleepless nights? Discover natural, research-backed supplements designed to calm your mind and support deep, restorative sleep.
From Ashwagandha and Magnesium to gentle sleep aids, our curated formulas help you unwind, rebalance, and feel like yourself again — naturally.
Trusted by thousands. Fast UK delivery. Wellness that works from the inside out.
Swanson Lion's Mane Mushroom - Full Spectrum 500mg - 60 caps
£8.95
Regular price
£10.95
Swanson Ashwagandha 450mg 100 Caps
£10.95
Regular price
£13.95
Swanson Lithium Orotate 5mg - 60 Caps
£9.95
Regular price
£11.00
Swanson Rhodiola Rosea Root 400mg - 100 Caps
£13.95
Regular price
£15.95
IBS, Bloating & Gut Health – Digestive Support That Works
Tired of bloating, discomfort, or unpredictable digestion? You’re not alone. At Probiotic.co.uk, we specialise in targeted supplements to support IBS relief, colon health, and long-term gut balance.
From our bestselling CDS22-formula probiotic to digestive enzymes and gentle gut-soothing blends, these customer favourites are trusted to restore comfort and improve daily wellbeing — naturally.
Fast UK delivery. Clinically backed. Formulated to help you feel your best every day.
Now Foods Super Enzymes Digestive - 90/180 tabs
From
£22.95
Regular price
£47.75
Now Foods Slippery Elm 400mg - 100 Veg Capsules
£13.95
Regular price
£14.95
Swanson Lactobacillus Gasseri - 60 Caps
£13.95
Regular price
£14.95
Swanson Probiotic + Prebiotic Fibre 500 million CFU - 60 Caps
£13.95
Regular price
£15.95
Candida & Thrush Relief – Balance Yeast Naturally
Candida is a natural yeast found in the body — but when it overgrows, it can trigger symptoms like fatigue, bloating, brain fog, and recurrent thrush.
This collection features targeted supplements designed to support candida cleanse, restore microbial balance, and help manage common symptoms naturally. From high-strength probiotics to antifungal herbs and gut-focused nutrients, these formulas are trusted by those seeking long-term relief and inner balance.
Expertly selected. Clean ingredients. Fast UK delivery from Probiotic.co.uk.
Now Foods Candida Support - 90 Veg Capsules
£21.95
Regular price
£23.95
Enzymedica Candidase Candida Support - 42 caps
£35.95
Regular price
£37.95
Enzymedica Candidase Extra Strength Candida Support - 42 caps
£49.95
Regular price
£54.95
Swanson Oregano Oil - 120 Softgels
£9.95
Regular price
£10.95
Now Foods Organic Inulin Prebiotic Pure Powder - 227g or 454g
From
£17.45
Regular price
£17.95
Now Foods Slippery Elm 400mg - 100 Veg Capsules
£13.95
Regular price
£14.95
Natural Weight Management – Balance, Burn & Support
Looking for a healthier, more sustainable way to manage your weight? This collection features supplements designed to support fat metabolism, appetite control, and blood sugar balance — naturally.
From clinically studied ingredients like Berberine and Green Tea Extract to metabolism-friendly probiotics and adaptogens, each product is chosen to support your goals without extremes.
No quick fixes — just trusted, science-led solutions to help you feel your best every step of the way.
Swanson Lactobacillus Gasseri - 60 Caps
£13.95
Regular price
£14.95
Swanson Berberine 400 mg 60 Caps
£17.95
Regular price
£24.95
Detox & Cleanse Support – Gently Reset from Within
Help your body rebalance and reset with supplements that support its natural detox pathways. From liver and colon support to full-body cleanse blends, this collection is designed to promote daily elimination, gut balance, and overall vitality — gently and effectively.
Featuring ingredients like Milk Thistle, Berberine, chlorella, and high-strength probiotics, our expertly curated formulas help flush toxins, reduce bloating, and support long-term wellness from the inside out.
Trusted ingredients. Real results. Fast UK delivery from Probiotic.co.uk.
Now Foods - Glutathione 500mg - 60/120 Caps
From
£34.95
Regular price
£39.95
Swanson Full Spectrum 500mg - Liver Support - 100 Caps
£8.95
Regular price
£11.00
Swanson Sulforaphane from Broccoli - 400 mcg 60 Caps
£9.95
Regular price
£12.95
Calm & Mood Support – Natural Anxiety Relief
Feel calmer, clearer, and more in control — naturally. This collection features trusted supplements known to help reduce stress, ease anxious feelings, and support overall emotional balance.
From adaptogens like Ashwagandha and Rhodiola, to mood-regulating Magnesium and L-Theanine, these science-backed solutions are designed to help calm your nervous system without harsh side effects.
Gentle yet effective. Expertly selected. Fast UK delivery from Probiotic.co.uk.
Now Foods - Glutathione 500mg - 60/120 Caps
From
£34.95
Regular price
£39.95
Swanson Full Spectrum 500mg - Liver Support - 100 Caps
£8.95
Regular price
£11.00
Swanson Sulforaphane from Broccoli - 400 mcg 60 Caps
£9.95
Regular price
£12.95
Focus & Brain Health – Clarity, Memory & Mental Performance
Support your brain with supplements that sharpen focus, boost memory, and enhance mental clarity. This collection features powerful nootropics and natural ingredients like Lion’s Mane Mushroom, Omega-3 fish oils, Rhodiola, and Ginkgo Biloba — all selected to help you think clearer, stay energised, and perform at your best.
Whether you’re tackling brain fog, studying, or improving cognitive longevity, these expert-backed formulas are designed to fuel your mind — naturally.
Cognitive support. Clean ingredients. Fast UK delivery.
Swanson Lion's Mane Mushroom - Full Spectrum 500mg - 60 caps
£8.95
Regular price
£10.95
Swanson Lithium Orotate 5mg - 60 Caps
£9.95
Regular price
£11.00
Doctor's Best High Absorption Magnesium - 120 Tabs
£20.95
Regular price
£23.95
Now Foods Vitamin D-3 High Potency 5,000 IU - 240 Softgels
£19.95
Regular price
£22.50
Energy & Vitality – Beat Fatigue, Boost Your Day Naturally
Feeling run-down, foggy, or constantly tired? You’re not alone — and there’s a natural way to recharge. This energising collection includes high-potency supplements that support physical stamina, mental clarity, and cellular energy production.
From energising adaptogens like Rhodiola and Ginseng, to essential nutrients like Vitamin B12, CoQ10, and Magnesium, every formula is selected to help fight fatigue and restore long-lasting vitality — without caffeine crashes.
Real energy. Real results. Delivered fast across the UK from Probiotic.co.uk.
Now Foods Sunflower Lecithin 1200mg - 200 Softgels
£27.95
Regular price
£30.00
Doctor's Best High Absorption Magnesium - 120 Tabs
£20.95
Regular price
£23.95
Swanson Rhodiola Rosea Root 400mg - 100 Caps
£13.95
Regular price
£15.95
Now Foods Vitamin D3 10,000 IU - 120 Soft Caps
£14.95
Regular price
£16.95
Now Foods Organic Inulin Prebiotic Pure Powder - 227g or 454g
From
£17.45
Regular price
£17.95
Now Foods Super Enzymes Digestive - 90/180 tabs
From
£22.95
Regular price
£47.75
Now Foods Candida Support - 90 Veg Capsules
£21.95
Regular price
£23.95
Now Foods - Glutathione 500mg - 60/120 Caps
From
£34.95
Regular price
£39.95
Swanson Supplements – Trusted Quality Since 1969
Discover Swanson, a globally trusted supplement brand known for delivering premium-quality formulas at accessible prices. Since 1969, Swanson has focused on science-backed ingredients, clean manufacturing, and outstanding value — making wellness easier for everyone.
From everyday essentials like vitamins, minerals, and herbal blends, to targeted support for immunity, digestion, joints, and more — this collection brings you the best of Swanson, shipped fast across the UK from Probiotic.co.uk.
Affordable excellence. Backed by decades of wellness expertise.
Swanson Lactobacillus Gasseri - 60 Caps
£13.95
Regular price
£14.95
Swanson Lithium Orotate 5mg - 60 Caps
£9.95
Regular price
£11.00
Swanson Sulforaphane from Broccoli - 400 mcg 60 Caps
£9.95
Regular price
£12.95
Swanson Ultimate 16 Strain Probiotic - 60 Caps
£12.95
Regular price
£14.95
Swanson Lactobacillus Gasseri - 60 Caps
£13.95
Regular price
£14.95
Swanson Lithium Orotate 5mg - 60 Caps
£9.95
Regular price
£11.00
Swanson Sulforaphane from Broccoli - 400 mcg 60 Caps
£9.95
Regular price
£12.95
Swanson Ultimate 16 Strain Probiotic - 60 Caps
£12.95
Regular price
£14.95
Blogs
CDS22-formula and Optibac Every Day are two popular probiotics in the UK, but they differ in strength, strains and clinical heritage. This neutral, evidence-based comparison explains how Optibac’s 5B CFU daily capsule compares with the much higher-strength 112B CFU De Simone Formulation. Helpful for UK readers researching everyday probiotics versus specialist formulations. Not medical advice.
Read more
A UK-focused, evidence-based comparison of probiotics for ulcerative colitis, IBS and pouchitis, including guideline positions and clinical trial summaries.
Read more
A factual, evidence-based UK comparison of CDS22-formula and Symprove, including strains, format, clinical studies and practical differences. Not medical advice.
Read moreExpert Guide: High-Strength Probiotics & The De Simone Formulation in the UK.
CDS22-formula is the original De Simone Formulation, a high-potency probiotic containing 8 specific strains of live bacteria. It is the most clinically studied probiotic formulation in the world, with over 200 peer-reviewed publications, and is widely used in the UK for managing complex gut issues like IBS, UC, and Pouchitis.
CDS22-formula contains the exact same 8-strain De Simone Formulation previously sold under the brand names Vivomixx and VSL#3 (prior to 2016). It is the identical "Original Formulation" produced to the same high-quality standards and proprietary manufacturing process.
High-strength probiotics like CDS22 are live cultures. To guarantee the 450 billion CFU (Colony Forming Units) potency through the expiry date, the product must be kept between 2-8°C. Probiotic.co.uk uses specialised temperature-controlled packaging and next-day UK delivery to ensure the bacteria remain live and effective.
While CDS22-formula is a food supplement, the De Simone Formulation it contains is recognized by many UK health professionals. We provide specialized wholesale portals for practitioners and offer high-potency options that meet the standards often recommended in clinical settings.
The UK’s Specialist in High-Potency Microbiome Support
Unmatched 450 Billion CFU Potency per Sachet
While standard high-street probiotics often contain between 1 and 10 billion bacteria, CDS22-formula delivers an intensive 450 Billion CFU dose. This 45x increase in potency ensures a high-concentration delivery of live beneficial bacteria, meeting the strict requirements for clinical-grade gut health protocols in the UK and Ireland.
The Original 8-Strain De Simone Formulation (DSF)
Authenticity is the core of our clinical heritage. We exclusively supply the original 8-strain formulation—a specific multi-strain blend (DSF) that has been the subject of over 200 peer-reviewed studies. By maintaining the exact ratios of the inventor-certified strains, we provide the identical science used in landmark gastroenterology trials for IBS, UC, and Pouchitis.
Certified Cold-Chain Logistics & UK Dispatch
Potency is only as good as the delivery. Every order of our high-strength probiotics is dispatched from our Lancashire-based facility via guaranteed cold-chain transit. We use temperature-controlled packaging and express next-day delivery across the UK to ensure the 450 Billion CFU count remains live, active, and effective upon arrival.
Company No: 638628 | UK VAT: 474869726 | EORI: GB474869726000
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