Clinical Gut Health Intelligence
Providing the latest research on the original De Simone Formulation (CDS22) and high-potency microbiome support in the UK. All content is clinically reviewed to ensure accuracy for patients and healthcare professionals.
The UK’s Specialist Hub for Probiotic Evidence & Gut Health Research
Welcome to the Probiotics UK & Gut Health Knowledge Hub, the central resource for evidence-based research on the original De Simone Formulation (CDS22). This hub provides UK readers, patients, and healthcare professionals with clinical guides, high-potency strain comparisons, and the latest gastroenterology updates dispatched from our Lancashire facility.
Probiotic.co.uk publishes UK-focused guides on probiotics, microbiome science, and digestive health. Articles reference guidance from the NHS, UK Food Standards Agency (FSA) regulations on food supplements, and peer-reviewed clinical research in gastroenterology and microbiome science where relevant.
Our editorial focus includes probiotics for IBS, ulcerative colitis, pouchitis, antibiotic-associated diarrhoea, microbiome restoration after antibiotics, and general digestive health support. Many guides discuss the Original De Simone Formulation (CDS22), a high-strength probiotic formulation studied in more than 200 peer-reviewed scientific publications.
Content is written for UK readers and reflects UK supplement regulations, NHS clinical pathways, and real-world patient questions commonly seen in gastroenterology practice. From our cold-chain facility in Chorley, Lancashire, we monitor developments in gut microbiome research and translate emerging science into clear guidance for clinicians, pharmacists, and informed consumers across the UK.
This pharmacy-grade guide applies strain-specific evidence, CFU viability, storage requirements, and UK regulatory criteria to evaluate leading probiotic products including CDS22, Symprove, Optibac, and Alflorex. Antibiotic timing protocol covered: 2-hour separation rule, 7–14 days post-course continuation, with reference to NHS and FSA guidance.
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Evidence-based UK guide to probiotics. Named clinical trials (Hill 2014, Ford 2018, Gionchetti 2000), FSA regulatory framework, five-point evaluation checklist, strain types, CFU guidance, and FAQ. Written for UK readers, patients, and healthcare professionals.
Read more- CDS22 contains 8 strains from the original De Simone formulation developed by Professor Claudio De Simone
- The formulation has been studied in over 80 peer-reviewed publications for IBS, ulcerative colitis, and pouchitis
- Referenced in ECCO IBD guidelines and American Gastroenterological Association (AGA) clinical guidance
- The original formulation was previously marketed in the UK as VSL#3 and Vivomixx
- Following a 2016 US court ruling, the De Simone IP was separated from the VSL#3 brand
- CDS22 is the only UK product carrying the original 8-strain formula at 450 billion CFU per sachet
- Available exclusively in the UK from Probiotic.co.uk, dispatched from Chorley, Lancashire