CDS22 vs Vivomixx Neo: Original De Simone Formulation Comparison (UK Guide)
TL;DR – Quick Answer
CDS22-formula contains the original De Simone Formulation once used in VSL#3 and later Vivomixx 450. The product sold today as Vivomixx Neo uses a new 9-strain formulation with no clinical trial history behind this recipe. If you are searching for the original clinically studied formulation, the option available in the UK is CDS22-formula.
Introduction
Many people searching for “Vivomixx UK”, “Vivomixx 450”, or “Vivomixx probiotic” do not realise that the original formulation has changed. This guide clearly explains the difference between CDS22-formula, which continues the original De Simone Formulation, and Vivomixx Neo, which is a revised 9-strain blend with a different strain profile.
CDS22-formula, the world’s most powerful probiotic. This formulation is the original 8-strain, 450-billion CFU probiotic blend. It was previously marketed as Vivomixx* (owned by Mendes SA) until 2025 and as VSL#3* (owned by Actial Srl) prior to that. No affiliation to these brands exists today.
What Is CDS22-formula?
- Contains the original De Simone Formulation
- 8 specific strains in fixed ratios
- 450 billion CFU per sachet
- Same formulation referenced in historical clinical studies
- Continuity with the formula previously found in VSL#3 (original) and Vivomixx 450
What Is Vivomixx Neo?
According to public retailer and manufacturer listings, Vivomixx Neo includes:
- 9 probiotic strains (a new “Neo” combination)
- Approximately 460 billion CFU per sachet
- Revised formulation including IMC 501, IMC 502, SP1 and others
- No clinical trial history on the Neo 9 formulation
- Does not contain the original De Simone Formulation
CDS22-formula vs Vivomixx Neo – High-Level Comparison
| Feature | CDS22-formula | Vivomixx Neo |
|---|---|---|
| Formulation | Original De Simone Formulation (8 strains) | New Neo 9 formulation (9 strains) |
| Clinical Evidence | Historically studied formulation with published trials | No trials published on Neo 9 blend |
| CFU per Sachet | 450 billion | ~460 billion |
| Strain Profile | Eight specific strains used in historic studies | Nine strains with revised ratios and new additions |
| Product Positioning | Continuation of the original scientific formulation | New alternative under the Vivomixx brand |
Strain-by-Strain Formulation Comparison
The strains and ratios used in Vivomixx Neo do not match the original De Simone Formulation previously found in VSL#3 and Vivomixx 450. CDS22-formula contains the exact same 8 clinically studied strains, while Vivomixx Neo contains a different 9-strain blend with no published clinical trials on this formulation.
The table below shows which strains are present in CDS22-formula (original De Simone Formulation) and in Vivomixx Neo 9, and how they are declared on the labels.
| Strain | CDS22-formula (Original De Simone Formulation) | Vivomixx Neo 9 (per sachet) |
|---|---|---|
| Streptococcus thermophilus |
Present S. thermophilus DSM 24731 / NCIMB 30438 Included in 450 billion CFU total |
Present S. thermophilus SP4 – 9 billion CFU |
| Bifidobacterium breve |
Present B. breve DSM 24732 / NCIMB 30441 Included in 450 billion CFU total |
Present B. breve Br8 – 9 billion CFU |
| Bifidobacterium longum |
Present B. longum DSM 24736 / NCIMB 30442 Included in 450 billion CFU total |
Not present – |
| Bifidobacterium infantis |
Present B. infantis DSM 24737 / NCIMB 30443 Included in 450 billion CFU total |
Not present – |
| Lactobacillus acidophilus |
Present L. acidophilus DSM 24735 / NCIMB 30439 Included in 450 billion CFU total |
Present L. acidophilus LA1 – 9 billion CFU |
| Lactobacillus plantarum |
Present L. plantarum DSM 24730 / NCIMB 30437 Included in 450 billion CFU total |
Present L. plantarum SP1 – 26 billion CFU L. plantarum 14D – 9 billion CFU |
| Lactobacillus paracasei |
Present L. paracasei DSM 24733 / NCIMB 30445 Included in 450 billion CFU total |
Present L. paracasei IMC 502 – 190 billion CFU |
| Lactobacillus delbrueckii subsp. bulgaricus |
Present L. delbrueckii subsp. bulgaricus DSM 24734 / NCIMB 30440 Included in 450 billion CFU total |
Not present – |
| Lactococcus lactis |
Not present – |
Present L. lactis SP38 – 9 billion CFU |
| Bifidobacterium animalis subsp. lactis |
Not present – |
Present B. animalis subsp. lactis BL1 – 9 billion CFU |
See what customers across the UK are saying about CDS22-formula:
Clinical Evidence Overview
The original De Simone Formulation has been referenced in more than 200 scientific publications. These studies were conducted using earlier products that contained the original formulation. Vivomixx Neo does not use this formulation, and the Neo 9 blend does not currently appear in published peer-reviewed trials.
Are They Interchangeable?
No. Although both are high-strength probiotics, they contain different strains, different ratios, and different formulation logic. Clinical evidence cannot be transferred from one formulation to another.
When People Choose CDS22-formula
- If they previously used VSL#3 (original) or Vivomixx 450
- If they want continuity with the clinically studied 8-strain formulation
- If they want clarity around strain identity and scientific lineage
- If they prefer a formulation with a well-documented history
When People Choose Vivomixx Neo
- Brand familiarity with the Vivomixx name
- Preference for a 9-strain blend
- Availability from local or online retailers
How to Decide – Quick Framework
- Prefer evidence continuity? Choose CDS22-formula.
- Prefer the Vivomixx brand? Choose Vivomixx Neo.
- Previously used original Vivomixx 450? CDS22-formula maintains that formulation lineage.
- Unsure? Show both information sheets to your healthcare professional.
Summary
- Vivomixx 450 (original) once contained the De Simone Formulation.
- Vivomixx Neo is not the same product and uses a different recipe.
- CDS22-formula contains the original 8-strain formulation referenced in earlier studies.
- Clinical trial data does not apply to the Neo 9 blend.
- For formulation continuity, CDS22-formula is the direct successor.
Where to Buy CDS22-formula
View the full CDS22 range here:
https://probiotic.co.uk/collections/cds22-formula
Frequently Asked Questions
Is Vivomixx still available in the UK?
The original Vivomixx 450 is no longer supplied. The product sold today is Vivomixx Neo, which uses a different formulation.
Is Vivomixx Neo the same as Vivomixx 450?
No. Vivomixx Neo is a newly formulated 9-strain blend and does not contain the original De Simone Formulation.
Which probiotic contains the original De Simone Formulation?
CDS22-formula contains the original 8-strain De Simone Formulation.
Can I switch from Vivomixx Neo to CDS22-formula?
They are different formulations. Users who previously used Vivomixx 450 often choose CDS22-formula for continuity of formulation.
Does Vivomixx Neo have clinical evidence?
No clinical trials have been published on the Neo 9 formulation.
About the Author
This article was prepared by the editorial team at Probiotic.co.uk, the official distributor of CDS22-formula in the UK and Ireland. The team reviews publicly available product information and scientific literature to help readers understand the differences between high-strength probiotic formulations.
Scientific References and Sources
- De Simone Formulation – Official Scientific Site
- 80+ Clinical Studies – Medical References for the Original De Simone Formulation
- 200+ Reviewed Articles – Scientific Papers Related to the Original De Simone Formulation
- Cheng FS et al. “Probiotic mixture VSL#3: Overview of Basic and Clinical Studies in Chronic Diseases.” World J Clin Cases, 2020.
- Trinchieri V et al. “Effectiveness and Safety of a Multistrain Probiotic Formulation …” Comparative analysis of original vs modified formulations, 2017.
- Correction Notice: Clarification that certain studies refer to the original pre-2016 De Simone Formulation (not later variants branded as VSL#3).
- Biagioli M et al. “Divergent Effectiveness of Multispecies Probiotics …” Demonstrates strain-specific and formulation-specific efficacy, 2019.
- ClinicalTrials.gov Identifier NCT01686698 – Trial of the Original De Simone Formulation in Cognitive Function and Quality of Life.