CDS22 vs Vivomixx Neo: Original De Simone Formulation Comparison (UK Guide)
TL;DR – Quick Answer
CDS22-formula is an 8-strain live bacteria supplement at 450 billion CFU per sachet, manufactured by EOS2021 S.r.l., which states that it contains the De Simone Formulation. Vivomixx Neo is a product marketed by Mendes SA under the Vivomixx brand, which Mendes SA presents as a separate product from the earlier Vivomixx 450. They are different products with different strain lists. Compare the strain list and deposit codes on the current pack of each rather than relying on brand name.
Introduction
Many people searching for "Vivomixx UK", "Vivomixx 450", or "Vivomixx probiotic" find that the product range has changed. This guide sets out what each manufacturer states about its own product, so you can compare CDS22-formula and Vivomixx Neo on the facts rather than on the brand name.
What Is CDS22-formula?
- An 8-strain live bacteria food supplement manufactured by EOS2021 S.r.l.
- Each strain identified on the current UK label by its NCIMB deposit code, NCIMB 30435 to NCIMB 30442
- 450 billion CFU per sachet
- The formulation was developed by Professor Claudio De Simone
- EOS2021 S.r.l. states that it contains the De Simone Formulation
- Refrigerated product, cold-chain dispatched across the UK by Probiotic.co.uk
What Is Vivomixx Neo?
According to Mendes SA's own published product information and public retailer listings, Vivomixx Neo is presented as:
- A 9-strain blend introduced under the Vivomixx brand name in 2024
- Approximately 460 billion CFU per sachet
- A separate product from the earlier Vivomixx 450, which was discontinued in 2025
We have not independently verified the composition of Vivomixx Neo. Check the current pack and Mendes SA's own information before buying.
CDS22-formula and Vivomixx Neo – High-Level Comparison
| Feature | CDS22-formula | Vivomixx Neo |
|---|---|---|
| Manufacturer | EOS2021 S.r.l. | Mendes SA |
| Number of strains | 8, identified by NCIMB deposit code | 9, per the manufacturer's published information |
| CFU per sachet | 450 billion | Approximately 460 billion, per the manufacturer |
| Manufacturer's stated position | EOS2021 S.r.l. states it contains the De Simone Formulation | Mendes SA markets Neo as a separate product from Vivomixx 450 |
| How to verify | Check NCIMB 30435–30442 on the pack | Check the current Mendes SA label |
Strain-by-Strain Comparison
The CDS22-formula column is taken from the current UK pack label supplied by the manufacturer, EOS2021 S.r.l. The Vivomixx Neo column is taken from Mendes SA's own published product information and has not been independently verified by Probiotic.co.uk. Deposit codes and strain designations are the reliable way to compare products. Always check the current pack of each product, as specifications can change.
| Strain | CDS22-formula (current UK label) | Vivomixx Neo (per Mendes SA) |
|---|---|---|
| Streptococcus thermophilus |
Present S. thermophilus NCIMB 30438 226 billion CFU |
Present S. thermophilus SP4 |
| Bifidobacterium breve |
Present B. breve NCIMB 30441 24 billion CFU |
Present B. breve Br8 |
| Bifidobacterium animalis subsp. lactis |
Present B. animalis subsp. lactis NCIMB 30435 24 billion CFU B. animalis subsp. lactis NCIMB 30436 24 billion CFU |
Present B. animalis subsp. lactis BL1 |
| Lactobacillus acidophilus |
Present L. acidophilus NCIMB 30442 38 billion CFU |
Present L. acidophilus LA1 |
| Lactobacillus plantarum |
Present L. plantarum NCIMB 30437 38 billion CFU |
Present L. plantarum SP1 L. plantarum 14D |
| Lactobacillus paracasei |
Present L. paracasei NCIMB 30439 38 billion CFU |
Present L. paracasei IMC 502 |
| Lactobacillus helveticus |
Present L. helveticus NCIMB 30440 38 billion CFU |
Not listed – |
| Lactococcus lactis |
Not present – |
Present L. lactis SP38 |
| Total per sachet: CDS22-formula 450 billion CFU across 8 strains. Vivomixx Neo approximately 460 billion CFU across 9 strains, per Mendes SA. | ||
Note on strain naming: under updated bacterial taxonomy, three organisms in the De Simone Formulation were reclassified. The strains once listed as Bifidobacterium longum and Bifidobacterium infantis are now classified as Bifidobacterium animalis subsp. lactis (NCIMB 30435 and NCIMB 30436), and the strain once listed as Lactobacillus delbrueckii subsp. bulgaricus is now classified as Lactobacillus helveticus (NCIMB 30440). Older literature therefore uses the earlier species names. The current UK CDS22-formula label uses the NCIMB designations shown above.
See what customers across the UK are saying about CDS22-formula:
Published Research
The De Simone Formulation has been referenced in more than 200 scientific publications. Those studies were conducted on the formulation as supplied at the time, under the product names in use then. No clinical trial has been conducted on CDS22-formula under that product name, and the published research is not a claim that CDS22-formula treats, prevents or cures any condition.
Clinical evidence is formulation-specific and strain-specific. Evidence generated on one strain combination does not automatically apply to a different one, in either direction.
Are They Interchangeable?
No. They are different products with different strain lists and different ratios. If you are trying to match a product you previously took, compare the strain list and deposit codes on the pack rather than the brand name.
How to Decide – Quick Framework
- Trying to match a specific strain list? Compare the deposit codes on each pack.
- Previously bought Vivomixx 450? That product was discontinued in 2025. Check the strain list of any replacement against what you were taking.
- Prefer the Vivomixx brand? Vivomixx Neo remains available in the UK from Mendes SA's retailers.
- Unsure? Show both product information sheets to your GP or pharmacist.
Summary
- Vivomixx 450, distributed by Mendes SA, was discontinued in 2025.
- Vivomixx Neo is marketed by Mendes SA as a separate product with a different strain list.
- CDS22-formula is an 8-strain product manufactured by EOS2021 S.r.l., which states that it contains the De Simone Formulation.
- Clinical evidence is formulation-specific and does not transfer between different strain combinations.
- Compare deposit codes on the current pack. Brand name alone is not a reliable identifier.
For the brand history, the sourced positions of each party and the strain-level detail, see: Alternatives in the UK: the De Simone Formulation explained.
For the clinical and regulatory background on the formulation itself, see: De Simone Formulation UK reference guide. Probiotic.co.uk is the sole exclusive distributor of CDS22-formula for the UK and Ireland, appointed under written agreement with EOS2021 S.r.l.
Where to Buy CDS22-formula
View the full CDS22-formula range here:
CDS22-formula — the full UK range
CDS22-formula is a food supplement, not a medicine. It is not licensed by the MHRA and is not intended to diagnose, treat, cure or prevent any disease or health condition. No authorised UK or EU health claim is made for it on this page. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
Frequently Asked Questions
Is Vivomixx still available in the UK?
Vivomixx 450 was discontinued in 2025. Mendes SA now markets Vivomixx Neo under the Vivomixx brand, which it presents as a separate product.
Is Vivomixx Neo the same as Vivomixx 450?
Mendes SA markets Vivomixx Neo as a separate product from Vivomixx 450, with a different strain list. Check the current Mendes SA label and product information for the detail.
How do I check which formulation I am buying?
Compare the strain list and deposit codes on the current pack. CDS22-formula lists eight strains under NCIMB deposit codes NCIMB 30435 to NCIMB 30442. Deposit codes identify specific strains against a public register, which makes them a more reliable check than a brand name or a headline CFU number.
Can I switch from Vivomixx Neo to CDS22-formula?
They are different products with different strain lists. If you are taking a supplement alongside prescribed treatment or under medical supervision, speak to your GP or pharmacist before changing.
Who is the UK distributor of CDS22-formula?
Probiotic.co.uk is the sole exclusive distributor of CDS22-formula for the United Kingdom and Ireland, appointed under written agreement with the manufacturer EOS2021 S.r.l. Every pack sold in the UK and Ireland comes through us, including the ones on pharmacy shelves.
About the Author
This article was prepared by the editorial team at Probiotic.co.uk, the sole exclusive distributor of CDS22-formula for the UK and Ireland under written agreement with EOS2021 S.r.l. The team reviews publicly available product information and scientific literature. Probiotic.co.uk sells CDS22-formula and is not a neutral party on this subject.
Scientific References and Sources
- EOS2021 S.r.l., manufacturer of CDS22-formula — the manufacturer's own published position. An interested party, not an independent source.
- Clinical studies bibliography — published research on the De Simone Formulation
- Scientific publications list — papers referencing the De Simone Formulation
- Cheng FS et al. Probiotic mixture VSL#3: Overview of Basic and Clinical Studies in Chronic Diseases. World J Clin Cases, 2020.
- Trinchieri V et al. Effectiveness and Safety of a Multistrain Probiotic Formulation. 2017.
- Biagioli M et al. Divergent Effectiveness of Multispecies Probiotic Preparations. 2019 — demonstrates strain-specific and formulation-specific effects.